Developmental Nicotine Exposure Alters Synaptic Input to Hypoglossal Motoneurons and Is Associated with Altered Function of Upper Airway Muscles
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چکیده
منابع مشابه
Developmental nicotine exposure alters neurotransmission and excitability in hypoglossal motoneurons.
Hypoglossal motoneurons (XII MNs) control muscles of the mammalian tongue and are rhythmically active during breathing. Acetylcholine (ACh) modulates XII MN activity by promoting the release of glutamate from neurons that express nicotinic ACh receptors (nAChRs). Chronic nicotine exposure alters nAChRs on neurons throughout the brain, including brain stem respiratory neurons. Here we test the h...
متن کاملInfluence of developmental nicotine exposure on spike-timing precision and reliability in hypoglossal motoneurons.
Smoothly graded muscle contractions depend in part on the precision and reliability of motoneuron action potential generation. Whether or not a motoneuron generates spikes precisely and reliably depends on both its intrinsic membrane properties and the nature of the synaptic input that it receives. Factors that perturb neuronal intrinsic properties and/or synaptic drive may compromise the tempo...
متن کاملDevelopmental nicotine exposure alters neurotransmission and excitability in hypoglossal 1 motor neurons 2 3
34 35 Hypoglossal motor neurons (XII MNs) control muscles of the mammalian tongue, and are 36 rhythmically active during breathing. Acetylcholine (ACh) modulates XII MN activity by 37 promoting the release of glutamate from neurons that express nicotinic ACh receptors (nAChRs). 38 Chronic nicotine exposure alters nAChRs on neurons throughout the brain, including brainstem 39 respiratory neurons...
متن کاملTitle: Influence of Developmental Nicotine Exposure on Spike Timing Precision & Reliability in Hypoglossal Motoneurons Abbreviated Title: Developmental Nicotine and Motoneuron Intrinsic Properties Author Names and Affiliations
Title: Influence of developmental nicotine exposure on spike timing precision & 1 reliability in hypoglossal motoneurons 2 3 Abbreviated title: developmental nicotine and motoneuron intrinsic properties 4 5 Author names and affiliations: 6 Gregory L. Powell, Richard B. Levine , Amanda M. Frazier, Ralph F. Fregosi 2 7 Departments of Physiology, Neuroscience and Biomedical Engineering, The 8 Univ...
متن کاملDevelopmental nicotine exposure alters AMPA neurotransmission in the hypoglossal motor nucleus and pre-Botzinger complex of neonatal rats.
Developmental nicotine exposure (DNE) impacts central respiratory control in neonates born to smoking mothers. We previously showed that DNE enhances the respiratory motor response to bath application of AMPA to the brainstem, although it was unclear which brainstem respiratory neurons mediated these effects (Pilarski and Fregosi, 2009). Here we examine how DNE influences AMPA-type glutamatergi...
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ژورنال
عنوان ژورنال: eneuro
سال: 2019
ISSN: 2373-2822
DOI: 10.1523/eneuro.0299-19.2019